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KMID : 0383819900370010093
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Tuberculosis and Respiratory Diseases
1990 Volume.37 No. 1 p.93 ~ p.99
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A Study on the 2.3-DPG (Diphosphoglycerate) Activity in Red Blood Cells of the Patients with Bronchial Asthma, COPD (Chronic Obstructive Pulmonary Disease) and Pulmonary Tuberculosis
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김정권/Jeong Kwon Kim
이충섭/이용철/이수영/송하숙/이양근/Choong Seob Lee/Yong Chul Lee/Soo Yeong Lee/Ha Sook Song/Yang Geun Lee
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Abstract
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Red blood cells synthesize 2.3-DPG that shifts the oxygen dissociation curve to right
and consequently, increase the oxygen utilization and metabolism in the peripheral tissue.
Recently there are many reports on the 2.3-DPG activity in red blood cell and related
factor, ie PH, Temperature hemoglobin, anoxia, bicarbonate, and high altitude. On these
fundamental basis, clinically Ⅰ investigate the relationship be tween 2.3-DPG activity in
red blood cell and known environmental factors in bronchial astsma, COPD and
pulmonary tuberculosis.
The result doesn't show significant change of 2.3-DPG activity according to each
disease, its duration, and its severity. But, it shows a correlation between 2.3-DPG
activity and environmental factors. Especially a arterial oxygen partial pressure shows a
reverse correlation with 2.3-DPG activity. These results suggest that 2.3-DPG activity
mainly depends on the arterial oxygen partial pressure.
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